| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200-1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | DRRS; HSAL4; ZNF797; dJ1112F19.1 |
| Entrez GeneID | 57167 |
| clone | 4B6G4 |
| WB Predicted band size | 112kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Purified recombinant fragment of human SALL4 (AA: 96-359) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于SALL4抗体的3篇代表性文献(示例为虚构，实际文献需通过数据库查询获取)：
1. **"SALL4 as a Diagnostic Marker for Germ Cell Tumors"**
- 作者：Cao D, Guo J.
- 摘要：研究验证SALL4抗体在生殖细胞肿瘤(如精原细胞瘤、卵黄囊瘤)中的高特异性表达，建议将其作为鉴别诊断的关键免疫组化标记物。
2. **"SALL4 Expression in Hepatocellular Carcinoma"**
- 作者：Wang Y, et al.
- 摘要：发现SALL4在肝细胞癌中异常表达，并与肿瘤侵袭性相关，提示其抗体可用于肝癌病理诊断及预后评估。
3. **"SALL4 Antibody in Ovarian and Testicular Cancers"**
- 作者：Jones R, Patel K.
- 摘要：比较SALL4与其他生殖细胞标记物(如OCT4)的敏感性，证实SALL4抗体在卵巢和睾丸恶性肿瘤中的诊断价值。
**建议**：通过PubMed或Google Scholar搜索关键词"SALL4 antibody immunohistochemistry"或"SALL4 diagnostic marker"获取真实文献，优先选择高被引研究(2010年后)。
SALL4 antibody is a diagnostic and research tool targeting the SALL4 protein, a transcription factor critical in embryonic development and stem cell pluripotency. Belonging to the Spalt-like (SAL) family, SALL4 contains zinc finger domains that regulate gene expression by binding DNA. During embryogenesis, SALL4 maintains self-renewal in pluripotent stem cells and primordial germ cells. Postnatally, its expression is largely restricted to germ cells but is aberrantly reactivated in various cancers, making it a valuable biomarker.
In diagnostic pathology, SALL4 antibody is widely used to identify germ cell tumors (e.g., seminoma, yolk sac tumor) and certain somatic cancers, including subsets of acute myeloid leukemia, hepatocellular carcinoma, and gastric adenocarcinoma. Its nuclear staining pattern in immunohistochemistry (IHC) aids in distinguishing these malignancies from morphologically similar tumors.
Research applications focus on SALL4's role in cancer progression, stemness, and chemoresistance. Studies highlight its interaction with pathways like Wnt/β-catenin and OCT4. suggesting therapeutic targeting potential. However, interpretation requires caution, as low-level SALL4 expression may occur in normal tissues. Two major isoforms, SALL4A and SALL4B, exhibit functional differences, though commercial antibodies often detect both.
Overall, SALL4 antibody bridges clinical diagnostics and molecular research, offering insights into developmental biology and oncogenesis while guiding precision oncology strategies.
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