| WB | 1/500 - 1/2000 | Human, Mouse, Monkey |
| IF | 咨询技术 | Human, Mouse, Monkey |
| IHC | 1/200-1/1000 | Human, Mouse, Monkey |
| ICC | 技术咨询 | Human, Mouse, Monkey |
| FCM | 1/200-1/400 | Human, Mouse, Monkey |
| Elisa | 1/10000 | Human, Mouse, Monkey |
| Aliases | CD56; NCAM; MSK39 |
| Entrez GeneID | 4684 |
| clone | 5B1G11 |
| WB Predicted band size | 94.6kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Monkey |
| Immunogen | Purified recombinant fragment of human NCAM1 (AA: extra(568-708)) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于NCAM1抗体的3篇参考文献示例(文献信息为虚构，仅供格式参考)：
1. **文献名称**: "A monoclonal antibody targeting NCAM1 inhibits tumor growth in metastatic neuroblastoma models"
**作者**: Smith A, et al.
**摘要**: 本研究开发了一种靶向NCAM1的单克隆抗体，通过体外和体内实验证明其能特异性结合NCAM1阳性肿瘤细胞，抑制神经母细胞瘤的迁移和增殖，并显著减少小鼠模型中转移灶的形成。
2. **文献名称**: "NCAM1 antibody-based flow cytometry analysis reveals differential expression in Alzheimer’s disease brain tissues"
**作者**: Chen L, et al.
**摘要**: 文章利用高特异性NCAM1抗体进行流式细胞术和免疫组化分析，发现阿尔茨海默病患者脑组织中NCAM1表达水平显著下调，提示其可能与突触功能损伤相关。
3. **文献名称**: "Characterization of a novel anti-NCAM1 antibody for neural stem cell isolation"
**作者**: Tanaka K, et al.
**摘要**: 该研究报道了一种新型兔源多克隆抗体的开发与验证，该抗体能高效识别NCAM1胞外域，成功用于从啮齿类动物大脑中分选神经干细胞，并证实其无交叉反应性。
(注：以上文献为示例，实际引用时请以真实发表的论文为准。)
Neural cell adhesion molecule 1 (NCAM1. also known as CD56) is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. It plays critical roles in cell-cell adhesion, neuronal development, synaptic plasticity, and immune regulation. NCAM1 mediates homophilic binding (NCAM-NCAM interactions) and heterophilic interactions with extracellular matrix components, facilitating cell migration, axon guidance, and tissue morphogenesis. Its expression is prominent in the nervous system, but it is also detected in immune cells (e.g., natural killer cells) and certain cancers, including gliomas, melanomas, and multiple myeloma.
NCAM1 antibodies are essential tools for studying its biological functions and pathological implications. They enable the detection of NCAM1 isoforms (e.g., 120. 140. and 180 kDa variants arising from alternative splicing) and post-translational modifications, such as polysialylation (PSA-NCAM), which modulates cell adhesion. In research, these antibodies are used in techniques like Western blotting, immunohistochemistry, and flow cytometry to explore NCAM1's role in neural repair, cancer metastasis, and immune responses. Clinically, NCAM1 antibodies have diagnostic potential in identifying CD56-positive tumors and are being investigated for therapeutic targeting. Aberrant NCAM1 expression or glycosylation is linked to neurological disorders (e.g., schizophrenia, Alzheimer’s) and cancer progression, underscoring its biomedical relevance.
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