| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200-1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | FSGS7; PAPRS |
| Entrez GeneID | 5076 |
| clone | 2C8C6 |
| WB Predicted band size | 44.7kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human PAX2 (AA: 194-304) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于PAX2抗体的3篇参考文献，按文献名称、作者和摘要内容简要概括：
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1. **文献名称**：*PAX2 in Oncogenesis: Diagnostic and Therapeutic Implications*
**作者**：Smith A, et al.
**摘要**：研究探讨了PAX2蛋白在多种癌症(如肾细胞癌、卵巢癌)中的异常表达，利用特异性PAX2抗体进行免疫组化分析，发现其过表达与肿瘤侵袭性相关，提示其作为潜在治疗靶点的可能性。
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2. **文献名称**：*PAX2 Antibody as a Marker for Renal Progenitor Cells in Development and Disease*
**作者**：Jones R, et al.
**摘要**：通过PAX2抗体的染色，验证了其在胚胎肾脏发育中标记肾祖细胞的作用，并发现其在成人肾脏损伤后再生过程中重新激活，为肾脏修复机制研究提供工具。
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3. **文献名称**：*Technical Validation of PAX2 Antibody Specificity in Immunohistochemistry*
**作者**：Lee H, et al.
**摘要**：系统评估了市售PAX2抗体的特异性，通过敲除细胞模型和正常/病变组织对比，确认其在泌尿系统肿瘤诊断中的可靠性，为临床病理应用提供实验依据。
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(注：以上文献信息为示例性质，实际引用时需根据真实文献调整。)
The PAX2 antibody is a valuable tool in developmental biology and pathology research, targeting the PAX2 protein encoded by the *PAX2* gene, a member of the paired box (PAX) transcription factor family. PAX proteins are critical for embryonic development, particularly in organogenesis. PAX2 plays a pivotal role in the formation of the kidneys, eyes, ears, and central nervous system by regulating cell differentiation, proliferation, and tissue patterning. Its expression is tightly controlled during development, with downregulation in mature tissues, though reactivation occurs in certain pathological conditions.
In research, PAX2 antibodies are widely used to identify PAX2-expressing cells in immunohistochemistry (IHC), immunofluorescence (IF), and Western blot (WB) assays. They help map developmental pathways and study congenital anomalies, such as renal-coloboma syndrome, linked to *PAX2* mutations. Clinically, PAX2 antibodies serve as diagnostic markers in oncology, as PAX2 is aberrantly expressed in cancers like renal cell carcinoma, ovarian cancer, and neuroendocrine tumors. Its re-expression in malignancies highlights its potential role in tumorigenesis and metastasis.
Structurally, PAX2 contains a paired DNA-binding domain and a partial homeodomain, enabling interaction with specific DNA sequences to regulate target genes. Antibodies targeting epitopes within these domains ensure specificity in detecting functional PAX2 isoforms. Researchers must validate PAX2 antibodies for cross-reactivity, as PAX family members (e.g., PAX8) share conserved regions. Overall, PAX2 antibodies bridge developmental biology and clinical diagnostics, offering insights into both normal organogenesis and disease mechanisms.
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