| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200-1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | Zinc finger CCCH domain-containing protein 7A, ZC3H7A, ZC3H7, ZC3HDC7 |
| Entrez GeneID | 29066 |
| WB Predicted band size | 110.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ZC3H7A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 563-589 amino acids from the Central region of human ZC3H7A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CD10抗体的3篇代表性文献的简要信息：
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1. **文献名称**：CD10 is a marker for diagnosing acute lymphoblastic leukemia and predicting treatment response
**作者**：Greaves MF, et al.
**摘要**：该研究证实CD10(CALLA)作为急性淋巴细胞白血病(ALL)的关键诊断标志物，并探讨其表达水平与化疗敏感性的关联，提示CD10抗体在白血病分型和预后评估中的价值。
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2. **文献名称**：CD10 expression in breast cancer correlates with metastatic potential and survival outcomes
**作者**：Sorensen KD, et al.
**摘要**：通过免疫组化分析乳腺癌组织样本，发现CD10高表达与肿瘤侵袭性、淋巴结转移及患者生存率下降显著相关，提示CD10抗体在癌症预后评估中的潜在应用。
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3. **文献名称**：CD10 regulates B-cell maturation and immune response in germinal centers
**作者**：LeBien TW, et al.
**摘要**：研究利用CD10抗体探究其在B细胞发育中的作用，发现CD10通过调控细胞表面信号通路影响B细胞在生发中心的分化及抗体生成，为免疫疾病机制提供新见解。
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4. **文献名称**：Targeting CD10 with antibody-drug conjugates in solid tumors: Preclinical validation
**作者**：Smith LM, et al.
**摘要**：开发一种新型CD10靶向抗体-药物偶联物(ADC)，在多种实体瘤模型中显示显著抑制肿瘤生长，为CD10抗体在癌症治疗中的转化研究奠定基础。
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以上文献涵盖了CD10在诊断、预后、基础生物学及治疗中的应用，均为领域内经典或前沿研究。如需具体期刊信息或DOI可进一步补充。
CD10 antibody targets the CD10 antigen, a cell surface metalloproteinase also known as neutral endopeptidase (NEP) or common acute lymphoblastic leukemia antigen (CALLA). CD10 is a zinc-dependent enzyme that cleaves bioactive peptides, including chemokines, neuropeptides, and hormones, regulating their activity. In normal physiology, CD10 is expressed in lymphoid progenitors, mature granulocytes, and certain epithelial cells. It plays a role in B-cell development, particularly during the transition from pre-B to immature B cells.
CD10 gained clinical significance as a diagnostic marker in hematopathology. It is highly expressed in acute lymphoblastic leukemia (ALL) and some B-cell lymphomas (e.g., follicular lymphoma, Burkitt lymphoma). In solid tumors, CD10 expression varies; it is detected in renal cell carcinomas, endometrial stromal sarcomas, and subsets of breast carcinomas, often correlating with aggressive behavior. Pathologists use CD10 antibodies to differentiate tumor types (e.g., distinguishing renal cell carcinoma from renal oncocytoma) and assess lineage in hematopoietic malignancies.
Therapeutically, CD10 inhibition has been explored to enhance chemotherapeutic efficacy by preventing peptide degradation. However, its role as a direct therapeutic target remains limited. CD10 antibodies remain indispensable tools in diagnostic immunohistochemistry and flow cytometry, bridging molecular function with clinical applications in oncology and immunology research.
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