Mouse Monoclonal MUC5AC Antibody

The MUC5AC antibody is a crucial tool for studying the MUC5AC mucin, a gel-forming secretory glycoprotein predominantly expressed in epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. As a member of the mucin family, MUC5AC plays a vital role in mucosal defense by forming a viscoelastic barrier against pathogens, toxins, and mechanical stress. Its overexpression is linked to pathological conditions such as chronic respiratory diseases (e.g., asthma, COPD), cystic fibrosis, and certain cancers (e.g., gastric, lung). The MUC5AC antibody enables researchers to detect, quantify, and localize this mucin in tissues and biological fluids using techniques like immunohistochemistry, ELISA, and Western blotting. Both monoclonal and polyclonal variants exist, with monoclonal antibodies offering higher specificity for distinct epitopes and polyclonal antibodies providing broader detection across species. These antibodies are essential for investigating mucus hypersecretion mechanisms, evaluating therapeutic interventions, and exploring MUC5AC's role as a biomarker. Recent studies also highlight its involvement in immune modulation and tumor microenvironment interactions. Validation of antibody specificity remains critical, as cross-reactivity with other mucins (e.g., MUC5B) can occur. Overall, MUC5AC antibodies are indispensable in advancing research on mucosal biology and related diseases.