| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200-1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200-1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | CSS9; MRD27 |
| Entrez GeneID | 6664 |
| clone | 8D5D4 |
| WB Predicted band size | 46.7kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human SOX11 (AA: 1-250) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
+ +
以下是关于SOX11抗体的3篇参考文献及其摘要概括：
---
1. **"SOX11 expression in mantle cell lymphoma"**
- **作者**: Ek S, Dictor M, Jerkeman M, et al.
- **摘要**: 该研究通过免疫组化分析SOX11在套细胞淋巴瘤(MCL)中的表达，发现SOX11抗体可作为MCL诊断的敏感标志物，并揭示其与患者预后的潜在关联。
2. **"SOX11 antibody specificity in B-cell neoplasms"**
- **作者**: Dictor M, Ek S, Sundberg M, et al.
- **摘要**: 文章评估了不同SOX11抗体的特异性，证实其在区分MCL与其他B细胞淋巴瘤中的可靠性，并强调了抗体选择对病理诊断的重要性。
3. **"SOX11 as a neuroblastoma-associated antigen"**
- **作者**: Sernan MT, Haldosen LA, Hollingsworth RE, et al.
- **摘要**: 研究利用SOX11抗体检测神经母细胞瘤样本，发现SOX11高表达与肿瘤分化程度相关，提示其在神经发育和癌症中的双重作用。
4. **"Prognostic impact of SOX11 in ovarian carcinoma"**
- **作者**: Sørensen PH, Lomnytska M, Høgdall E, et al.
- **摘要**: 该研究通过SOX11抗体检测卵巢癌组织，发现其表达水平与肿瘤侵袭性和患者生存率显著相关，支持SOX11作为预后评估工具。
---
以上文献涵盖SOX11抗体在淋巴瘤、神经肿瘤及实体瘤中的应用，重点包括诊断标志物验证、抗体特异性分析及预后关联研究。
SOX11 (SRY-box transcription factor 11) is a member of the SOX gene family, which plays critical roles in embryonic development, cell fate determination, and tissue differentiation. SOX11 is involved in neurogenesis, osteogenesis, and regulating progenitor cell proliferation. Notably, it is transiently expressed during embryonic development but is typically absent in most adult tissues. Aberrant SOX11 expression has been linked to several cancers, including mantle cell lymphoma (MCL), medulloblastoma, and epithelial ovarian cancer, where it often correlates with aggressive disease and poor prognosis. In MCL, SOX11 overexpression serves as a diagnostic biomarker, distinguishing it from other B-cell lymphomas.
Antibodies targeting SOX11 are widely used in research and diagnostics to detect its expression via immunohistochemistry (IHC), Western blot (WB), or immunofluorescence (IF). These antibodies aid in studying SOX11's functional roles in development and disease, particularly its oncogenic mechanisms. Validated SOX11 antibodies are essential for accurate diagnostic applications, especially in lymphoma subtyping. However, variability in antibody specificity and sensitivity requires careful validation using knockout controls or siRNA-based approaches. Commercial SOX11 antibodies are typically raised against epitopes in the N-terminal or central regions of the protein, with monoclonal and polyclonal variants available. Their utility extends to exploring SOX11's potential as a therapeutic target in cancers driven by its dysregulation.
×
