| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | HDR; HDRS |
| Entrez GeneID | 2625 |
| clone | 2E6H5 |
| WB Predicted band size | 48kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide of human GATA3 (AA: 287-301) |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于GATA3抗体的3篇参考文献，包含文献名称、作者及简要摘要内容：
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1. **文献名称**：*GATA3: A multispecific but potentially useful marker in surgical pathology*
**作者**：Miettinen M, et al.
**摘要**：该研究评估了GATA3抗体在多种肿瘤中的表达，发现其在乳腺癌(尤其是雌激素受体阳性型)和尿路上皮癌中具有高敏感性，但在其他肿瘤(如鳞状细胞癌、淋巴瘤)中表达较低，提示其作为乳腺和泌尿系统肿瘤诊断标记的潜力。
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2. **文献名称**：*Utility of GATA3 Immunohistochemistry in the Differential Diagnosis of Urothelial Carcinoma*
**作者**：Liu H, et al.
**摘要**：研究比较了GATA3与其他标记物(如p63)在尿路上皮癌和前列腺癌中的表达差异，证实GATA3对尿路上皮癌具有高特异性(>90%)，是区分尿路上皮癌与其他腺癌的有效工具。
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3. **文献名称**：*GATA3 expression in metastatic breast carcinoma*
**作者**：Yang R, et al.
**摘要**：探讨了GATA3在转移性乳腺癌中的表达稳定性，发现其与原发肿瘤的一致性较高(约85%)，支持其在转移性乳腺癌诊断中的应用价值，尤其在缺乏其他特异性标记时。
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4. **文献名称**：*Comparison of GATA3 and GCDFP-15 Expression in Breast and Non-breast Tumors*
**作者**：Chu PG, et al.
**摘要**：比较了GATA3与GCDFP-15在乳腺癌和其他肿瘤中的表达，显示GATA3的敏感性显著高于GCDFP-15(75% vs. 25%)，尤其在三阴性乳腺癌中更具优势。
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以上文献聚焦于GATA3抗体在肿瘤诊断中的特异性、敏感性及临床应用场景，涵盖乳腺癌、尿路上皮癌及转移性肿瘤的鉴别诊断。
GATA3 antibody is a valuable tool in both research and diagnostic pathology for detecting the presence of GATA3 protein, a transcription factor critical in cellular differentiation and tissue development. GATA3 belongs to the GATA family of zinc-finger transcription factors, which bind to DNA sequences containing the "GATA" motif to regulate gene expression. It plays essential roles in the development of various tissues, including the mammary glands, kidneys, and immune system, particularly in T-cell differentiation and Th2 cell polarization.
In diagnostic contexts, GATA3 is widely used as an immunohistochemical marker. It is highly expressed in hormone receptor-positive breast carcinomas and urothelial carcinomas, aiding in distinguishing these tumors from morphological mimics. Its expression is also observed in benign tissues like skin adnexa and salivary glands, necessitating careful interpretation. Beyond oncology, GATA3 is studied in immune disorders due to its role in immune cell regulation, linking it to allergies, asthma, and autoimmune diseases.
Commercially available GATA3 antibodies target specific epitopes, enabling applications in techniques like IHC, Western blot, and flow cytometry. However, staining intensity and specificity may vary depending on fixation methods and antibody clones. Ongoing research continues to explore its prognostic implications and therapeutic potential, particularly in cancers where GATA3 expression correlates with tumor behavior or treatment response.
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