| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Entrez GeneID | 1266 |
| clone | 6D4B10 |
| WB Predicted band size | 36.4kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CNN3 (AA: 26-130) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是基于学术文献特征的模拟参考文献示例(仅供参考，建议通过学术数据库核实具体文献)：
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1. **"CNN3 Antibody Characterization in Smooth Muscle Phenotype Modulation"**
*作者：Yamashiro S, et al. (2018)*
摘要：研究验证了CNN3抗体的特异性，发现CNN3在血管平滑肌细胞表型转换中起关键作用，其表达水平与细胞迁移能力正相关。
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2. **"Calponin 3 as a Biomarker in Breast Cancer Invasion: Immunohistochemical Analysis"**
*作者：Li J, Wang H. (2020)*
摘要：通过CNN3抗体免疫组化检测，揭示CNN3在乳腺癌组织中的高表达与肿瘤侵袭深度及淋巴结转移显著相关，提示其预后评估潜力。
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3. **"Development of a Monoclonal CNN3 Antibody for Skeletal Muscle Studies"**
*作者：Hsieh CM, et al. (2019)*
摘要：报道了一种新型CNN3单克隆抗体的开发，验证其在骨骼肌发育模型中的适用性，证实CNN3在肌细胞分化中的动态表达变化。
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4. **"CNN3-mediated Cytoskeletal Remodeling in Glioblastoma Progression"**
*作者：Park K, et al. (2021)*
摘要：利用CNN3抗体进行功能研究，发现抑制CNN3表达可减少胶质母细胞瘤细胞的伪足形成和体外侵袭能力，提示其作为治疗靶点的可能性。
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**注意**：以上为模拟示例，实际文献需通过 **PubMed/Google Scholar** 以关键词 "CNN3 antibody" 或 "Calponin 3" 检索获取。推荐结合 **癌症研究、细胞骨架** 等领域筛选近期论文。
CNN3 (Calponin 3) is a member of the calponin family of actin-binding proteins, which regulate cytoskeletal dynamics and cellular contractility. It is expressed in smooth muscle cells, non-muscle cells, and various tissues, playing roles in cell migration, adhesion, and mechanical signaling. CNN3 interacts with actin filaments, myosin, and other cytoskeletal components, modulating cell shape and motility. Its function is implicated in physiological processes like wound healing and pathological conditions such as cancer metastasis, fibrosis, and cardiovascular diseases.
CNN3 antibodies are essential tools for studying its expression, localization, and interactions. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate CNN3's involvement in cellular mechanisms. Research has linked abnormal CNN3 expression to tumor progression (e.g., breast cancer, glioblastoma) and vascular remodeling, highlighting its potential as a biomarker or therapeutic target. However, its precise regulatory pathways remain partially understood, necessitating further exploration. Commercially available CNN3 antibodies vary in specificity across species and isoforms, requiring validation for experimental accuracy. Ongoing studies aim to clarify CNN3's dual roles in cell stabilization versus motility, bridging gaps in cytoskeletal biology and disease pathology.
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