| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | PVALB; myoglobgin |
| Entrez GeneID | 4151 |
| clone | 3B6D5 |
| WB Predicted band size | 17.2kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human MB (AA: 2-154) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于MB抗体(如抗髓鞘碱性蛋白抗体)的模拟参考文献示例(非真实文献，仅供格式参考)：
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1. **文献名称**：*Autoantibodies to Myelin Basic Protein in Multiple Sclerosis*
**作者**：Kies, M.W., Alvord, E.C.
**摘要**：研究多发性硬化症(MS)患者血清中抗髓鞘碱性蛋白(MBP)抗体的存在及其病理意义，发现抗体水平与疾病活动性相关，提示其可能参与脱髓鞘过程。
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2. **文献名称**：*Experimental Allergic Encephalomyelitis: Role of Anti-MBP Antibodies*
**作者**：Bournaud, R., et al.
**摘要**：通过动物模型探究抗MBP抗体在实验性自身免疫性脑脊髓炎(EAE)中的作用，证实抗体可通过血脑屏障加剧炎症反应和髓鞘损伤。
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3. **文献名称**：*Anti-MBP Antibodies as a Biomarker in Neurological Disorders*
**作者**：Sellebjerg, F., et al.
**摘要**：评估抗MBP抗体作为神经退行性疾病生物标志物的潜力，发现其在MS和视神经脊髓炎中特异性较高，但需结合其他指标提高诊断准确性。
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4. **文献名称**：*Monoclonal Anti-MBP Antibodies: Production and Therapeutic Potential*
**作者**：Warrington, A.E., et al.
**摘要**：报道开发靶向MBP的单克隆抗体，探索其在抑制自身免疫反应和保护髓鞘完整性中的治疗潜力，为免疫调节疗法提供新思路。
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注：以上文献为模拟内容，实际研究需查阅PubMed、Web of Science等数据库获取真实文献。
MB antibodies, also known as anti-myelin basic protein (anti-MBP) antibodies, are autoantibodies targeting myelin basic protein (MBP), a key component of the myelin sheath in the central and peripheral nervous systems. MBP plays a critical role in maintaining the structural integrity of myelin, which insulates nerve fibers and ensures efficient signal transmission. The discovery of MB antibodies emerged from research on autoimmune demyelinating disorders, particularly multiple sclerosis (MS), where immune-mediated damage to myelin is a hallmark.
In the 1970s-1980s, studies identified elevated MB antibody levels in the cerebrospinal fluid (CSF) and serum of MS patients, suggesting their potential role in disease pathogenesis. These antibodies are thought to contribute to myelin degradation by binding to MBP, triggering complement activation or antibody-dependent cellular cytotoxicity. However, their specificity and diagnostic utility remain controversial, as MB antibodies are also detected in other neurological conditions (e.g., encephalitis, stroke) and even in healthy individuals.
Despite limited clinical application, MB antibodies continue to serve as research tools for understanding autoimmune mechanisms in demyelination. Recent studies explore their interaction with genetic and environmental factors, such as Epstein-Barr virus infection, which may influence autoantibody production. Ongoing investigations aim to clarify their pathogenic significance and potential as biomarkers for disease subtypes or therapeutic response in MS and related disorders.
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