| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | Kelch-like protein 12, CUL3-interacting protein 1, DKIR homolog, hDKIR, KLHL12, C3IP1 |
| Entrez GeneID | 59349 |
| WB Predicted band size | 63.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This KLHL12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 376-404 amino acids from the C-terminal region of human KLHL12. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于“MB抗体”(假设为 **髓鞘碱性蛋白抗体**，即抗-MBP抗体)的3篇代表性文献名称、作者及摘要概括：
---
1. **文献名称**：*Autoantibodies to myelin basic protein in multiple sclerosis patients: diagnostic and pathogenic implications*
**作者**：Berger T, et al.
**摘要**：研究分析了多发性硬化症(MS)患者血清中抗MBP抗体的存在与疾病活动的关系，发现其与急性复发期相关，提示可能作为疾病活动的生物标志物。
2. **文献名称**：*The role of anti-myelin antibodies in the pathogenesis of experimental autoimmune encephalomyelitis*
**作者**：Genain CP, et al.
**摘要**：通过动物模型证明抗MBP抗体可增强中枢神经系统炎症反应，表明其在实验性自身免疫性脑脊髓炎(EAE)中具有协同致病作用。
3. **文献名称**：*Anti-MBP antibodies are associated with gray matter atrophy in progressive multiple sclerosis*
**作者**：Khalil M, et al.
**摘要**：通过影像学和血清学分析，发现进展型MS患者的抗MBP抗体水平与灰质萎缩程度正相关，提示其参与神经退行性过程。
---
**备注**：若“MB抗体”指向其他靶标(如膜联蛋白MB型)，建议进一步明确抗原背景以便精准推荐文献。
MB antibodies, primarily associated with myelin basic protein (MBP), have been studied extensively in the context of autoimmune demyelinating diseases, particularly multiple sclerosis (MS). MBP is a critical structural component of the myelin sheath that insulates nerve fibers in the central nervous system (CNS). In the 1970s, researchers identified autoantibodies targeting MBP in the cerebrospinal fluid (CSF) and serum of MS patients, suggesting their potential role in myelin destruction. These antibodies, along with T-cell-mediated responses, contribute to the inflammatory attack on myelin, leading to impaired nerve signaling and neurological deficits.
While early studies emphasized MB antibodies as biomarkers for MS, their diagnostic specificity remains debated due to their presence in other conditions, such as encephalomyelitis and traumatic brain injury. Experimental models, like experimental autoimmune encephalomyelitis (EAE), demonstrated that MBP immunization could induce demyelination, reinforcing the link between autoimmunity to MBP and CNS pathology. However, the heterogeneity of MS has shifted focus toward broader autoantibody panels, including those targeting other myelin proteins (e.g., MOG, PLP) or non-protein antigens.
Recent advancements highlight the complexity of antibody-mediated mechanisms in demyelination, with MB antibodies now viewed as part of a multifaceted immune response rather than standalone pathogenic agents. Therapeutic strategies, such as B-cell depletion therapies, indirectly address antibody-related damage. Ongoing research aims to clarify the precise role of MB antibodies in disease progression and their utility in personalized treatment approaches.
×
