| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | ADAM8; MS2; CD156a |
| Entrez GeneID | 101 |
| clone | 3B10D7 |
| WB Predicted band size | 88.8kDa |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD156 (AA: extra 17-156) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CD156(ADAM17)抗体的参考文献示例，包括文献名称、作者及摘要概述：
1. **文献名称**: *"A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells"*
**作者**: Black, R.A. 等
**摘要**: 该研究首次克隆并鉴定了ADAM17(TACE)，证明其通过切割跨膜TNF-α释放可溶性形式，揭示了其在炎症中的关键作用。研究还开发了特异性抗体以阻断该酶活性，为后续治疗策略奠定基础。
2. **文献名称**: *"Anti-ADAM17 monoclonal antibody therapy for inflammatory diseases and cancer"*
**作者**: Moss, M.L. 等
**摘要**: 综述了抗ADAM17单克隆抗体的开发进展，强调其在抑制炎症性疾病(如类风湿性关节炎)和肿瘤生长中的潜力。实验表明，抗体可有效阻断EGFR配体脱落，抑制肿瘤细胞增殖。
3. **文献名称**: *"Development of a human anti-ADAM17 antibody for pancreatic cancer therapy"*
**作者**: Li, X. 等
**摘要**: 研究团队开发了一种人源化抗ADAM17抗体，体外和体内实验显示其能显著抑制胰腺癌细胞侵袭和转移，并通过阻断Notch通路增强化疗敏感性。
4. **文献名称**: *"Therapeutic targeting of ADAM17 with a monoclonal antibody in inflammatory bowel disease"*
**作者**: Brown, K.A. 等
**摘要**: 该研究利用抗ADAM17抗体在小鼠结肠炎模型中验证治疗效果，结果显示抗体通过减少促炎因子(如TNF-α和IL-6)释放，显著缓解肠道炎症和病理损伤。
**注**：上述文献为示例，实际引用时需核实具体来源及细节。
CD156 antibody targets CD156. a cell surface antigen also known as ADAM8 (A Disintegrin And Metalloproteinase 8). ADAM8 is a transmembrane glycoprotein belonging to the ADAM family, which plays roles in proteolysis, cell adhesion, and signaling. Structurally, it contains a metalloproteinase domain, disintegrin-like domain, and a cytoplasmic tail, enabling interactions with extracellular matrix components and cell surface receptors.
CD156/ADAM8 is implicated in inflammatory and pathological processes, including leukocyte migration, neuroinflammation, and cancer progression. Studies highlight its overexpression in certain cancers (e.g., lung, breast, glioblastoma), where it promotes tumor invasion, metastasis, and angiogenesis by modulating extracellular matrix remodeling and growth factor signaling.
CD156 antibodies are primarily used as research tools to investigate ADAM8's biological functions and mechanisms in disease models. Monoclonal antibodies against ADAM8 have shown potential in preclinical studies to inhibit its metalloproteinase activity or block protein-protein interactions, reducing tumor growth and inflammation in vivo. Additionally, CD156 antibodies aid in diagnostic applications, such as detecting ADAM8 expression in tissues or biofluids as a biomarker for disease monitoring.
Despite promising findings, therapeutic applications remain exploratory, with challenges including specificity, off-target effects, and optimal delivery. Ongoing research focuses on engineering antibody-based therapies (e.g., conjugated antibodies, bispecific formats) to enhance efficacy in targeting ADAM8-driven pathologies.
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