Mouse Monoclonal CD42B Antibody

The CD42b antibody targets the glycoprotein Ib alpha (GPIbα), a component of the GPIb-IX-V receptor complex expressed on platelet surfaces. This complex plays a critical role in primary hemostasis by mediating platelet adhesion to von Willebrand factor (vWF) at sites of vascular injury. CD42b (GPIbα) is essential for platelet activation, aggregation, and thrombus formation. Antibodies against CD42b are widely used in research and diagnostics to identify and quantify platelets or megakaryocytes via techniques like flow cytometry or immunohistochemistry. They also help study platelet-related disorders, such as Bernard-Soulier syndrome (caused by GPIb-IX-V defects) or immune thrombocytopenia (ITP), where autoantibodies may target GPIbα. Clinically, CD42b antibodies aid in monitoring platelet transfusions or assessing bone marrow megakaryocyte production. Additionally, they contribute to thrombosis research by exploring pathways that regulate platelet-vWF interactions, offering insights into antithrombotic therapies. Due to its specificity, CD42b remains a key tool in understanding platelet biology and related pathologies.