| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | GP1BA; BSS; GP1B; VWDP; GPIbA; BDPLT1; BDPLT3; DBPLT3; GPIbalpha; CD42b-alpha |
| Entrez GeneID | 2811 |
| clone | 6H6B11 |
| WB Predicted band size | 71.5kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD42B (AA: extra 17-183) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CD42B抗体的3篇参考文献及其摘要概述：
1. **文献名称**：*CD42b (GPIbα) plays a critical role in platelet clearance during sepsis*
**作者**：Zhang et al. (2018)
**摘要**：研究探讨CD42B在脓毒症中血小板减少症的作用，发现CD42B抗体通过促进巨噬细胞吞噬血小板加速其清除，揭示了其在脓毒症病理中的关键机制。
2. **文献名称**：*Anti-CD42b antibody induces platelet activation and promotes thrombosis in a murine model*
**作者**：Smith et al. (2020)
**摘要**：利用小鼠模型证明CD42B抗体会激活血小板表面受体，导致异常聚集和血栓形成，提示该抗体可能参与自身免疫性血栓疾病的发病过程。
3. **文献名称**：*Development of a monoclonal anti-CD42b antibody for diagnostic applications in immune thrombocytopenia*
**作者**：Lee et al. (2019)
**摘要**：报道一种新型CD42B单克隆抗体的开发，验证其在免疫性血小板减少症(ITP)诊断中的高特异性，为临床检测提供新工具。
(注：以上文献为示例，实际引用时需核对真实来源及作者信息。)
CD42B, also known as glycoprotein Ibα (GPIbα), is a key platelet surface receptor component of the GPIb-IX-V complex, which plays a critical role in primary hemostasis and thrombosis. The CD42B antibody specifically targets the GPIbα subunit, a 140-kDa transmembrane protein encoded by the GP1BA gene. This receptor mediates platelet adhesion to von Willebrand factor (VWF) at sites of vascular injury under high shear stress, initiating platelet activation and aggregation.
CD42B antibodies are widely used in research and diagnostics to study platelet function and quantify GPIbα expression. In clinical settings, they aid in diagnosing inherited platelet disorders like Bernard-Soulier syndrome (BPS), characterized by GPIb-IX-V deficiency. Monoclonal CD42B antibodies (e.g., clone SZ2) are employed in flow cytometry to identify platelet populations, assess activation states, or detect autoantibodies in immune thrombocytopenia (ITP).
Additionally, CD42B antibodies have therapeutic implications. Some inhibit GPIbα-VWF interactions to prevent pathological thrombosis, while others are explored for targeting platelets in inflammation or cancer metastasis. Challenges include balancing hemostatic safety in antithrombotic therapies. Overall, CD42B antibodies remain vital tools for understanding platelet biology and advancing hematologic disease management.
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