| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | P2U; HP2U; P2U1; P2UR; P2Y2; P2RU1; P2Y2R |
| Entrez GeneID | 5029 |
| clone | 4F11E7 |
| WB Predicted band size | 42.3kDa |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human P2RY2 (AA: extra mix) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于P2RY2抗体的3篇示例参考文献(注：以下内容为模拟文献示例，实际文献需通过学术数据库检索验证)：
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1. **文献名称**: *P2RY2 Receptor Antibody Characterization in Airway Inflammation Models*
**作者**: Smith A. et al.
**摘要**: 研究通过免疫组化和流式细胞术验证了P2RY2抗体的特异性，发现其在慢性阻塞性肺疾病(COPD)模型中高表达，提示其作为炎症标志物的潜力。
2. **文献名称**: *Targeting P2RY2 with Monoclonal Antibodies Attenuates Cancer Metastasis*
**作者**: Lee J. & Zhang H.
**摘要**: 开发了一种靶向P2RY2的单克隆抗体，体外实验显示其能抑制肿瘤细胞迁移，并在小鼠乳腺癌模型中减少肺转移灶形成。
3. **文献名称**: *P2RY2 Antibody-Based Imaging in Neurodegenerative Disorders*
**作者**: Müller C. et al.
**摘要**: 利用放射性标记的P2RY2抗体进行脑部PET成像，发现阿尔茨海默病模型小鼠脑内P2RY2表达显著上调，表明其与神经炎症相关。
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**建议检索关键词**：
- "P2RY2 antibody validation"
- "P2RY2 therapeutic targeting"
- "P2RY2 in disease models"
可通过PubMed、Google Scholar或Web of Science等平台查找真实文献。
P2RY2 (P2Y2 receptor) is a G protein-coupled receptor (GPCR) that belongs to the purinergic receptor family, which responds to extracellular nucleotides like ATP and UTP. It plays a critical role in mediating cellular responses to tissue injury, inflammation, and mechanical stress by regulating processes such as ion transport, mucus secretion, cell proliferation, and immune cell activation. P2RY2 is widely expressed in epithelial, endothelial, immune, and neural tissues, highlighting its involvement in diverse physiological and pathological pathways. Dysregulation of P2RY2 signaling has been implicated in diseases including cystic fibrosis, cancer, chronic inflammation, and fibrosis, making it a potential therapeutic target.
Antibodies targeting P2RY2 are essential tools for studying its expression, localization, and function. They enable detection of receptor levels in tissues or cell lines via techniques like Western blot, immunohistochemistry, and flow cytometry. Additionally, P2RY2 antibodies are used to investigate receptor activation mechanisms, ligand interactions, and downstream signaling cascades. In therapeutic research, neutralizing antibodies or antibody-based inhibitors are explored to block P2RY2 activity in conditions like inflammatory disorders or tumor progression. Despite progress, challenges remain in understanding tissue-specific signaling nuances and developing clinically viable antibody therapies. Overall, P2RY2 antibodies bridge basic research and translational applications, offering insights into receptor biology and disease modulation.
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