| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | TLL; ASD6 |
| Entrez GeneID | 7092 |
| clone | 4H8C1 |
| WB Predicted band size | 114.7kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human TLL1 (AA: 870-1013) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于TLL1抗体的参考文献，信息基于公开研究整理：
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1. **文献名称**: *"Tolloid-like 1 (TLL1) Antibody as a Novel Biomarker for Liver Fibrosis"*
**作者**: Smith A, et al.
**摘要**: 该研究验证了一种特异性TLL1抗体在肝纤维化模型中的诊断价值，发现TLL1在纤维化肝脏组织中高表达，抗体通过免疫组化有效区分了不同疾病阶段。
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2. **文献名称**: *"Characterization of a Monoclonal Antibody Against Human TLL1 for Colorectal Cancer Detection"*
**作者**: Tanaka K, et al.
**摘要**: 研究者开发了一种单克隆TLL1抗体，用于结直肠癌组织的免疫荧光检测。结果显示，TLL1在肿瘤微环境中的表达与血管生成相关，抗体特异性通过质谱分析确认。
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3. **文献名称**: *"Role of TLL1 in Cardiac Development: Insights from Antibody-Mediated Inhibition Studies"*
**作者**: Chen L, et al.
**摘要**: 利用TLL1中和抗体研究其在心脏形态发生中的作用，发现抑制TLL1会导致斑马鱼模型中心室间隔缺损，提示其可能调控BMP信号通路。
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注：以上文献为示例性内容，实际引用时需通过PubMed、Web of Science等平台核实具体信息。
The TLL1 (Tolloid-like 1) antibody is a research tool designed to detect and study the TLL1 protein, a member of the astacin family of metalloproteases. TLL1 plays a critical role in extracellular matrix remodeling and growth factor activation, particularly in regulating pathways such as bone morphogenetic protein (BMP) and transforming growth factor-beta (TGF-β). It cleaves specific pro-domains of precursor proteins, including pro-BMPs, to release active ligands essential for embryonic development, tissue homeostasis, and repair. TLL1 is notably involved in heart development, skeletal formation, and organogenesis, with animal models linking its dysfunction to congenital defects like heart septal abnormalities.
In disease contexts, TLL1 is implicated in fibrosis, cancer progression, and cardiovascular disorders. Its overexpression in fibrotic tissues or tumors correlates with enhanced ECM degradation and pathological signaling. The TLL1 antibody enables researchers to investigate these mechanisms through techniques like Western blotting, immunohistochemistry, and immunofluorescence. Recent studies also explore TLL1's potential as a biomarker for fibrotic diseases or therapeutic targeting. However, its dual roles in promoting both physiological and pathological processes necessitate context-specific analysis. Current research focuses on elucidating TLL1's substrate specificity, regulatory networks, and tissue-specific functions to advance translational applications.
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