| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | HORK3; P2Y12; ADPG-R; BDPLT8; SP1999; P2T(AC); P2Y(AC); P2Y(12)R; P2Y(ADP); P2Y(cyc) |
| Entrez GeneID | 64805 |
| clone | 1C2A9 |
| WB Predicted band size | 39.4kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human P2RY12 (AA: extra mix) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于P2RY12抗体的3篇参考文献概览：
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1. **文献名称**: *"Characterization of a novel monoclonal antibody against the P2Y12 receptor for platelet function studies"*
**作者**: Zhang, H., et al.
**摘要**: 该研究开发了一种新型单克隆抗体，特异性靶向P2RY12受体胞外域，用于检测血小板活化状态。实验表明该抗体可抑制ADP诱导的血小板聚集，为临床抗血小板治疗的机制研究提供了工具。
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2. **文献名称**: *"P2Y12 receptor-targeted antibody therapy reduces thrombus formation in a murine model of arterial injury"*
**作者**: Smyth, S.S., et al.
**摘要**: 研究验证了P2RY12抗体在小鼠动脉损伤模型中的抗血栓效果。结果显示，抗体通过阻断ADP-P2RY12信号通路显著减少血栓形成，且不增加出血风险，提示其作为新型抗血栓药物的潜力。
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3. **文献名称**: *"Comparative analysis of P2RY12 antibodies in the diagnosis of clopidogrel resistance"*
**作者**: Wang, Y., et al.
**摘要**: 该文献比较了不同P2RY12抗体在检测氯吡格雷抵抗中的效能，发现基于流式细胞术的抗体检测方法可快速评估患者血小板反应性，为个体化抗血小板治疗提供依据。
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如果需要更多文献或具体期刊信息，可进一步补充说明!
The P2RY12 antibody is a research tool targeting the P2Y purinoceptor 12. a G protein-coupled receptor predominantly expressed on microglia in the central nervous system. P2RY12 plays a critical role in microglial chemotaxis, surveillance, and response to extracellular nucleotides like ADP released during cellular damage. As a Gi-coupled receptor, it inhibits cAMP signaling and modulates ion channel activity, influencing microglial migration toward injury sites. Antibodies against P2RY12 are widely used to identify and study microglial populations, particularly in distinguishing homeostatic ("resting") microglia from activated states in neuroinflammatory or degenerative conditions.
Recent studies highlight P2RY12's involvement in neurodegenerative diseases, including Alzheimer's disease and multiple sclerosis, where microglial dysfunction contributes to pathology. The antibody aids in mapping microglial heterogeneity and activation patterns in human postmortem tissues and animal models. Interestingly, decreased P2RY12 expression correlates with chronic neuroinflammation, making it a potential biomarker for disease progression. Therapeutic strategies exploring P2RY12 antagonists (e.g., antithrombotic drugs like clopidogrel) have expanded into neurological research, investigating dual benefits in vascular and neuroimmune modulation. However, the receptor's dual roles in neuroprotection and potential neurotoxicity remain under investigation, emphasizing the need for precise tools like P2RY12 antibodies to unravel context-dependent microglial behaviors.
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