| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | ALL; CML; PHL; BCR1; D22S11; D22S662 |
| Entrez GeneID | 613 |
| clone | 1E11G12 |
| WB Predicted band size | 142.8kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human BCR (AA: 139-280) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于BCR(B细胞受体)抗体的3篇代表性文献，包括标题、作者和摘要概述：
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1. **标题**：*"B-cell antigen receptor signalling and its exploitation by the Epstein-Barr virus"*
**作者**：Reth, M. et al.
**摘要**：该综述探讨了B细胞受体(BCR)的信号传导机制，包括其与抗原结合后的激活过程、相关信号分子(如Syk和PI3K)的作用，以及EB病毒如何劫持BCR通路以促进B细胞存活和增殖。
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2. **标题**：*"Chronic lymphocytic leukemia antibodies recognize a common epitope adjacent to the B-cell receptor"*
**作者**：Dühren-von Minden, M. et al.
**摘要**：研究发现，慢性淋巴细胞白血病(CLL)患者的BCR抗体常靶向一个保守的抗原表位，揭示BCR自身异常激活可能是CLL发展的关键机制，为靶向治疗提供了新思路。
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3. **标题**：*"The initiation of B cell antigen receptor signaling: Lessons from molecular imaging"*
**作者**：Kurosaki, T. et al.
**摘要**：通过分子成像技术，本文揭示了BCR在抗原结合后的动态聚集过程及其对下游信号(如Ca²⁺动员和NF-κB激活)的调控，强调了BCR微结构域在信号启动中的重要性。
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如需具体文献年份或期刊信息，可进一步补充说明!
B cell receptors (BCRs) are membrane-bound immunoglobulins expressed on the surface of B lymphocytes, playing a central role in adaptive immunity. Each BCR consists of an antigen-binding fragment formed by two heavy and two light chains, and a signaling component (Igα/Igβ heterodimer) that transmits signals upon antigen recognition. BCRs are highly diverse due to V(D)J recombination, enabling recognition of a vast array of pathogens.
When a BCR binds to a specific antigen, it triggers intracellular signaling cascades, leading to B cell activation, proliferation, and differentiation into antibody-secreting plasma cells or memory B cells. This process is tightly regulated: weak signals may induce tolerance, while strong signals drive immune responses. BCRs also facilitate antigen internalization and presentation to T cells, critical for initiating T cell-dependent antibody responses, including affinity maturation and class switching.
Dysregulation of BCR signaling is linked to diseases like autoimmune disorders (e.g., lupus) and B cell malignancies (e.g., chronic lymphocytic leukemia). Therapeutic strategies targeting BCR pathways, such as inhibitors of Bruton’s tyrosine kinase (BTK), have shown efficacy in treating certain cancers. Overall, BCRs are essential for pathogen detection, immune memory, and maintaining immune homeostasis.
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