Mouse Monoclonal APBA2 Antibody

The APBA2 antibody targets the Amyloid Beta Precursor Protein (APP) Binding Family A Member 2 (APBA2), also known as X11-like (X11L) or Mint2. APBA2 is a neuronal adaptor protein that plays a critical role in synaptic function and intracellular signaling. It belongs to the Mint protein family, which interacts with the cytoplasmic domain of APP, a key protein implicated in Alzheimer’s disease (AD) pathogenesis. APBA2 contains a phosphotyrosine-binding (PTB) domain that mediates binding to APP, potentially influencing APP processing and the generation of amyloid-beta (Aβ) peptides, a hallmark of AD pathology. Beyond APP regulation, APBA2 participates in neurotransmitter release, synaptic vesicle trafficking, and receptor localization by interacting with components like Munc18-1 and membrane receptors. Its expression is predominantly observed in the brain, particularly in regions associated with cognition and memory. Antibodies against APBA2 are widely used in neuroscience research to study its expression patterns, protein-protein interactions, and role in neurodegenerative and neurodevelopmental disorders. These tools enable techniques such as Western blotting, immunohistochemistry, and co-immunoprecipitation, aiding in the exploration of APBA2’s physiological and pathological mechanisms. Dysregulation of APBA2 has been linked to synaptic dysfunction, highlighting its importance as a therapeutic or diagnostic target in neurological diseases.