| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | AS; HLAB; Bw-47; Bw-50; SPDA1; B-4901; B-5001; HLA-Cw; |
| Entrez GeneID | 3106 |
| clone | 2G7B10 |
| WB Predicted band size | 40.5kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human HLA-B (AA: 241-362) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下为3篇关于HLA-B抗体的参考文献及其摘要概括：
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1. **文献名称**：*"HLA antibody detection with single antigen beads: Clinical impact on transplant outcomes"*
**作者**：Terasaki PI, et al.
**摘要**：研究利用单抗原微珠技术(SAB)检测HLA-B及其他HLA抗体，发现其与移植排斥反应(如肾移植失败)显著相关，强调精准检测HLA-B抗体对移植预后的重要性。
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2. **文献名称**：*"Antibody-mediated rejection in transplantation: Mechanisms and therapeutic strategies"*
**作者**：Colvin RB, et al.
**摘要**：综述HLA-B抗体在抗体介导的排斥反应(AMR)中的作用机制，包括补体激活和内皮细胞损伤，提出针对HLA抗体的干预策略(如血浆置换和B细胞靶向治疗)。
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3. **文献名称**：*"HLA-B antibodies in pregnancy: Implications for maternal-fetal health"*
**作者**：Kieran JM, et al.
**摘要**：探讨妊娠期女性产生HLA-B抗体的风险及其对胎儿的影响，发现母体抗体可能通过胎盘引发新生儿免疫性疾病，提示孕期HLA抗体筛查的必要性。
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以上文献涵盖HLA-B抗体在移植、病理机制及妊娠中的关键研究。如需具体期刊信息或年份，可进一步补充说明。
**Background of HLA-B Antibodies**
HLA-B antibodies target human leukocyte antigen (HLA)-B molecules, a critical component of the major histocompatibility complex (MHC) class I system. These antibodies are primarily implicated in immune-mediated reactions, such as transplant rejection and transfusion-related complications. HLA-B genes exhibit high polymorphism, contributing to diverse antigenic epitopes, which increases the risk of antibody development upon exposure to non-self HLA-B antigens through events like pregnancy, blood transfusions, or prior organ transplants.
Clinically, HLA-B antibodies are significant in solid organ and hematopoietic stem cell transplantation. Their presence can lead to hyperacute or antibody-mediated rejection by binding to donor HLA-B antigens, triggering complement activation and endothelial injury. Sensitization screening via solid-phase assays (e.g., single-antigen bead tests) is essential for donor-recipient compatibility assessment. Additionally, HLA-B antibodies are linked to autoimmune conditions, such as HLA-B27-associated ankylosing spondylitis, though their pathogenic role here remains less defined.
Research focuses on understanding epitope specificity, cross-reactivity patterns, and strategies to mitigate antibody production (e.g., desensitization protocols, immunosuppressive therapies). Advances in HLA typing and antibody detection technologies continue to refine transplant outcomes, emphasizing personalized approaches to manage HLA-B-related immune challenges.
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