| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | p72-Syk |
| Entrez GeneID | 6850 |
| clone | 3D1G10 |
| WB Predicted band size | 72kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human SYK (AA: 217-356) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于SYK抗体的3-4篇参考文献的简要总结(基于公开文献信息，可能存在简化或归纳)：
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1. **文献名称**：**"Spleen tyrosine kinase (SYK) as a therapeutic target in rheumatoid arthritis"**
**作者**：Weinblatt ME, et al.
**摘要内容**：该研究探讨了SYK在类风湿性关节炎(RA)发病机制中的作用，发现抑制SYK可减少促炎细胞因子释放和关节破坏。临床试验显示SYK抑制剂(如fostamatinib)可显著改善RA患者症状，支持SYK作为治疗靶点的潜力。
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2. **文献名称**：**"SYK is required for the activation of the B cell receptor and survival in chronic lymphocytic leukemia"**
**作者**：Chen L, et al.
**摘要内容**：研究揭示了SYK在慢性淋巴细胞白血病(CLL)中通过调控B细胞受体(BCR)信号通路促进癌细胞存活的作用。实验表明，靶向SYK的抗体或抑制剂可诱导CLL细胞凋亡，为SYK靶向治疗在血液肿瘤中的应用提供了依据。
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3. **文献名称**：**"SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma"**
**作者**：Davis RE, et al.
**摘要内容**：该研究分析了弥漫大B细胞淋巴瘤(DLBCL)中SYK介导的BCR持续信号传导机制，发现SYK过度活化促进肿瘤增殖。通过体外和动物模型验证，SYK抑制剂可显著抑制肿瘤生长，提示其在DLBCL治疗中的临床价值。
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4. **文献名称**：**"Targeting SYK signaling in autoimmune diseases"**
**作者**：Mócsai A, et al.
**摘要内容**：综述了SYK在自身免疫性疾病(如系统性红斑狼疮、银屑病)中的核心作用，总结了SYK抗体及小分子抑制剂通过阻断免疫细胞异常活化缓解疾病的实验证据，并讨论了其临床转化前景与挑战。
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**注**：以上内容基于领域内代表性研究方向归纳，具体文献细节需通过学术数据库(如PubMed)进一步检索确认。如需全文信息，建议提供具体研究主题或联系机构图书馆获取。
Spleen tyrosine kinase (SYK) is a cytoplasmic non-receptor tyrosine kinase involved in signal transduction across immune receptors. Initially identified in the spleen, SYK is expressed in hematopoietic cells, including B cells, T cells, mast cells, and macrophages. It plays a critical role in immunoreceptor signaling pathways, such as the B-cell receptor (BCR), Fc receptors, and integrins. SYK contains two tandem Src homology 2 (SH2) domains that bind phosphorylated immunoreceptor tyrosine-based activation motifs (ITAMs), enabling its activation and downstream signaling. This kinase regulates cellular processes like proliferation, differentiation, and phagocytosis, making it essential for immune responses and inflammation.
SYK antibodies are tools used to detect or inhibit SYK in research and clinical contexts. In research, they help study SYK's expression, activation, and interaction partners via techniques like Western blotting, immunohistochemistry, or flow cytometry. Clinically, aberrant SYK activity is linked to autoimmune diseases (e.g., rheumatoid arthritis) and cancers (e.g., lymphoma, leukemia), driving interest in SYK-targeted therapies. Small-molecule SYK inhibitors and monoclonal antibodies are being explored to modulate pathological signaling. For example, fostamatinib, a SYK inhibitor, is approved for immune thrombocytopenia. However, challenges like off-target effects and resistance necessitate further optimization. SYK antibodies thus serve dual roles: as investigative reagents to unravel immune mechanisms and as potential therapeutics in precision medicine.
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