| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Entrez GeneID | 22803 |
| clone | 9F7G11 |
| WB Predicted band size | 108.5kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human XRN2 (AA: 398-547) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于XRN2抗体的3篇示例参考文献(注：以下为虚构示例，实际文献请通过PubMed或Google Scholar检索确认)：
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1. **标题**: *XRN2 Antibody Validation in RNA Degradation Studies*
**作者**: Johnson M, et al.
**摘要**: 本研究通过Western blot和免疫荧光验证了XRN2抗体的特异性，证明其在人细胞系中可有效检测内源性XRN2蛋白，并用于探究XRN2在核内RNA降解通路中的作用。
2. **标题**: *XRN2-Mediated Transcription Termination Requires Antibody-Detectable Chromatin Binding*
**作者**: Thompson R, et al.
**摘要**: 利用XRN2抗体进行染色质免疫沉淀(ChIP)，发现XRN2与RNA聚合酶II的终止位点结合，调控基因3'端加工，提示其通过转录偶联机制发挥作用。
3. **标题**: *Role of XRN2 in Viral RNA Processing: Insights from Antibody-Based Knockdown*
**作者**: Silva P, et al.
**摘要**: 通过XRN2抗体敲低实验，结合RNA测序，揭示了XRN2在宿主细胞对抗RNA病毒入侵中的关键作用，特别是通过降解病毒RNA片段限制感染。
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**建议**：实际研究中，可访问以下资源获取文献：
- **PubMed**(搜索关键词：XRN2 antibody validation/function)
- **抗体公司技术文档**(如CST、Abcam的XRN2抗体产品页引用的文献)
- **领域内高引论文**(如Nature, Cell中关于RNA代谢的研究)
The XRN2 antibody is a crucial tool for studying the function of XRN2 (5'-3' exoribonuclease 2), a conserved eukaryotic enzyme involved in RNA processing and degradation. XRN2. a member of the XRN family, catalyzes the 5'→3' degradation of various RNA substrates, including aberrant transcripts, pre-rRNA processing byproducts, and specific non-coding RNAs. It plays a key role in transcription termination by resolving R-loop structures and promoting Pol II release, particularly at gene termini. XRN2 also participates in nuclear RNA surveillance, maintaining transcriptome integrity by eliminating improperly processed or damaged RNAs.
Antibodies targeting XRN2 are widely used in molecular biology research to investigate its localization, expression, and interactions with other factors (e.g., CPSF73 in transcription termination). These antibodies enable techniques like Western blotting, immunoprecipitation, and immunofluorescence, helping to dissect XRN2's roles in gene regulation, RNA metabolism, and genome stability. Recent studies highlight XRN2's involvement in cancer progression, neurological disorders, and viral infection responses, making its antibody a valuable reagent for disease mechanism research. Commercial XRN2 antibodies are typically raised against specific epitopes (human or mouse origin) and validated for specificity across applications.
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