Mouse Monoclonal RND3 Antibody

The RND3 antibody is a tool used to detect and study the RND3 protein, a member of the Rho GTPase family (also known as RhoE). Unlike classical Rho GTPases, RND3 lacks intrinsic GTPase activity and remains constitutively active, functioning as a regulator of cytoskeletal dynamics, cell migration, proliferation, and apoptosis. It antagonizes RhoA/ROCK signaling pathways, promoting stress fiber disassembly and reducing cell contractility. RND3 is implicated in diverse physiological and pathological processes, including cancer, neurological disorders, and cardiovascular diseases. In cancer, RND3 exhibits context-dependent roles, acting as either a tumor suppressor by inhibiting invasion and metastasis or an oncogene by enhancing survival under stress. Its dysregulation has been linked to tumor progression, chemoresistance, and poor prognosis. In neuroscience, RND3 interacts with proteins like p190RhoGAP to regulate dendritic spine formation and synaptic plasticity, suggesting relevance in neurodegenerative conditions. The RND3 antibody enables researchers to analyze its expression, localization, and interactions via techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Its development has advanced studies on RND3's molecular mechanisms, offering insights into therapeutic targeting for diseases associated with cytoskeletal dysfunction or aberrant Rho signaling.