| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | CBX; M31; MOD1; p25beta; HP1-BETA; HP1Hsbeta; HP1Hs-beta |
| Entrez GeneID | 10951 |
| clone | 2B7D6 |
| WB Predicted band size | 21.4kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CBX1 (AA: 1-185) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CBX1抗体的3篇模拟参考文献示例(基于典型研究方向，供参考)：
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1. **文献名称**: "CBX1 is essential for the assembly of PRC1-mediated higher-order chromatin structures"
**作者**: Tanaka Y, et al.
**摘要**: 本研究利用CBX1特异性抗体进行免疫荧光和染色质免疫沉淀(ChIP)，揭示了CBX1在PRC1复合体介导的染色质压缩和基因沉默中的关键作用，证实其通过维持异染色质结构调控胚胎干细胞分化。
2. **文献名称**: "Antibody-based profiling of CBX1 reveals its dynamic redistribution during mitosis"
**作者**: Sarma K, et al.
**摘要**: 通过Western blot和活细胞成像技术结合CBX1抗体，发现CBX1在细胞有丝分裂期从异染色质中解离并参与纺锤体组装，提示其在细胞周期调控中的双重功能。
3. **文献名称**: "CBX1 expression loss promotes genomic instability in aggressive lymphomas"
**作者**: Vidal E, et al.
**摘要**: 采用CBX1抗体的免疫组化分析显示，淋巴瘤组织中CBX1表达下调与异染色质缺失及基因组不稳定性显著相关，为靶向表观遗传失调提供了新依据。
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**注**：以上为模拟文献，实际引用时建议通过PubMed或Google Scholar检索真实文献(关键词：CBX1 antibody、PRC1、heterochromatin)。如需具体文献，可提供更新年份或研究领域进一步筛选。
The CBX1 antibody is a tool used to study the Chromobox homolog 1 (CBX1) protein, a member of the Polycomb group (PcG) family. CBX1. also known as HP1β (Heterochromatin Protein 1β), plays a critical role in epigenetic regulation by mediating gene silencing through chromatin modification. It is a key component of heterochromatin, facilitating the formation of compact chromatin structures by binding to trimethylated lysine 9 on histone H3 (H3K9me3), a hallmark of transcriptionally repressive heterochromatin. This interaction is essential for maintaining genomic stability, telomere integrity, and proper chromosome segregation during cell division.
CBX1 antibodies are widely employed in research to investigate its localization, expression, and function in cellular processes such as differentiation, senescence, and cancer. They are used in techniques like Western blotting, immunofluorescence, chromatin immunoprecipitation (ChIP), and immunohistochemistry. Dysregulation of CBX1 has been linked to various cancers, where its overexpression or mislocalization may contribute to tumor progression by silencing tumor suppressor genes.
These antibodies are typically validated for specificity using knockout cell lines or siRNA-mediated knockdown to ensure accurate detection. Researchers select CBX1 antibodies based on target epitopes, species reactivity (e.g., human, mouse), and application compatibility. Understanding CBX1's role through these antibodies provides insights into epigenetic mechanisms and potential therapeutic targets for diseases linked to chromatin dysfunction.
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