| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | SLM1; SLM-1; bA535F17.1 |
| Entrez GeneID | 202559 |
| clone | 3D12C11 |
| WB Predicted band size | 39kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Purified recombinant fragment of human KHDRBS2 (AA: 160-349) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下为模拟生成的KHDRBS2抗体相关文献示例(请注意验证真实性和准确性)：
1. **"KHDRBS2 regulates alternative splicing in glioblastoma through RNA binding"**
- Author: Smith J, et al.
- 摘要：研究通过KHDRBS2抗体验证其在胶质母细胞瘤中的表达，发现其通过结合特定RNA序列调控可变剪接，影响肿瘤细胞侵袭性。
2. **"KHDRBS2 interacts with MAPK signaling pathway in prostate cancer"**
- Author: Zhang L, et al.
- 摘要：利用KHDRBS2抗体进行免疫共沉淀实验，揭示其与MAPK通路蛋白相互作用，促进前列腺癌细胞增殖。
3. **"KHDRBS2 expression correlates with poor prognosis in colorectal cancer"**
- Author: Tanaka K, et al.
- 摘要：通过免疫组化(KHDRBS2抗体)分析结直肠癌组织，发现高表达患者总生存期缩短，提示其作为预后标志物的潜力。
4. **"KHDRBS2 mutations disrupt RNA metabolism in autism spectrum disorders"**
- Author: García-Ramos A, et al.
- 摘要：在小鼠模型中结合KHDRBS2抗体染色，发现基因突变导致神经元RNA代谢异常，可能与自闭症相关突触功能障碍有关。
**提示**：以上为模拟内容，建议通过PubMed或Google Scholar检索真实文献(关键词：KHDRBS2 antibody, KHDRBS2 function)，并核对实验方法(如Western blot/IP/IHC等抗体应用场景)。
The KHDRBS2 antibody targets the KH domain-containing, RNA-binding, signal transduction-associated protein 2 (KHDRBS2), a member of the STAR family of RNA-binding proteins. KHDRBS2. also known as SLM1 or Sam68-like protein 1. is characterized by a conserved KH domain that facilitates RNA binding and protein-protein interactions. It plays roles in post-transcriptional gene regulation, including mRNA splicing, stability, and translation, by binding to specific RNA motifs.
Expressed predominantly in the brain, testes, and certain cancer tissues, KHDRBS2 is implicated in neuronal development, synaptic plasticity, and germ cell maturation. Studies suggest its involvement in cellular processes like differentiation, apoptosis, and signal transduction, particularly in response to extracellular stimuli. Dysregulation of KHDRBS2 has been linked to neurological disorders, infertility, and cancers, where it may act as an oncogene or tumor suppressor depending on context.
Antibodies against KHDRBS2 are essential tools for investigating its expression, localization, and molecular interactions. They are widely used in techniques such as Western blotting, immunohistochemistry, and RNA immunoprecipitation. Research utilizing these antibodies has advanced understanding of KHDRBS2's role in RNA metabolism and disease mechanisms, highlighting its potential as a therapeutic target or biomarker in cancer and neurological conditions.
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