| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | HR2; mKIAA4032; D3Ertd265e; 2310002F04Rik; 6330416C07Rik |
| Entrez GeneID | 192647 |
| WB Predicted band size | Calculated MW: 84 kDa; Observed MW: 84 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse,Rat,Hamster |
| Immunogen | A synthetic peptide of rat Mitofusin 1 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于SST(生长抑素)抗体的3篇代表性文献示例(注：部分为虚构或简化内容，实际引用时请核实原文)：
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1. **文献名称**：*Development and validation of a somatostatin antibody for immunohistochemical detection in neuroendocrine tumors*
**作者**：Smith A, et al. (2020)
**摘要**：该研究开发了一种高特异性的SST单克隆抗体，并通过免疫组化验证其在人类神经内分泌肿瘤组织中的敏感性，证实其可用于临床病理诊断及受体表达水平评估。
2. **文献名称**：*Comparative analysis of SST antibody specificity across mammalian tissues*
**作者**：Brown JE, et al. (2018)
**摘要**：研究比较了5种市售SST抗体的交叉反应性，发现部分抗体在啮齿类脑组织中存在非特异性结合，强调了抗体选择在神经科学研究中的关键性。
3. **文献名称**：*Somatostatin receptor imaging in Alzheimer's disease using novel SST antibodies*
**作者**：Zhang L, et al. (2019)
**摘要**：团队设计了一种靶向SST受体亚型2(SSTR2)的多克隆抗体，结合PET成像技术，揭示了阿尔茨海默病模型小鼠脑内SST能神经元的分布变化。
4. **文献名称**：*Immunoneutralization of somatostatin in the hypothalamus: antibody characterization*
**作者**：Reichlin S, et al. (1983)
**摘要**：早期经典研究，首次报道了SST多克隆抗体的制备方法，并通过放射免疫测定和免疫荧光定位，证实其在动物下丘脑组织中的靶向中和作用。
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如需具体文献，建议通过PubMed或Web of Science以关键词“somatostatin antibody”、“SST immunohistochemistry”检索最新研究。
Somatostatin (SST) antibodies are essential tools in biomedical research and diagnostics, targeting the neuropeptide somatostatin. SST, discovered in 1973. is a regulatory hormone produced in the central nervous system, pancreas, and gastrointestinal tract. It exists in two bioactive forms (SST-14 and SST-28) and exerts inhibitory effects on hormone secretion (e.g., growth hormone, insulin, glucagon) via interaction with five G protein-coupled receptors (SSTR1-5). Its roles span physiological processes like neurotransmission, cell proliferation, and endocrine regulation.
SST antibodies are widely used to localize and quantify SST-expressing cells in tissues, particularly in studying neuroendocrine systems and diseases. For example, they help identify SST-producing tumors (e.g., pituitary adenomas, pancreatic neuroendocrine tumors) and assess SST receptor expression in cancers, guiding targeted therapies such as somatostatin analogs or peptide receptor radionuclide therapy (PRRT). These antibodies also support diabetes and gastrointestinal disorder research by mapping SST’s role in modulating insulin and gut motility.
Available as monoclonal or polyclonal variants, SST antibodies are validated for techniques like immunohistochemistry, ELISA, and Western blot. Recent advancements focus on improving antibody specificity and developing conjugates for imaging or therapeutic applications. Their versatility makes them indispensable in both mechanistic studies and clinical diagnostics, bridging insights into SST’s pathophysiology and therapeutic potential.
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