| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | MODY11; MGC10442; BLK |
| Entrez GeneID | 640 |
| clone | 1E6 |
| WB Predicted band size | 58kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human BLK expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
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以下是关于BLK抗体的3篇代表性文献摘要(作者及研究内容简化)：
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1. **文献名称**: *Genetic variants near TNFAIP3 on 6q23 associated with systemic lupus erythematosus*
**作者**: Gateva V, et al.
**摘要**: 该研究通过全基因组关联分析(GWAS)发现，BLK基因区域的单核苷酸多态性(SNPs)与系统性红斑狼疮(SLE)显著相关，提示BLK在B细胞受体信号通路中的异常可能参与SLE的自身免疫发病机制。
2. **文献名称**: *The B cell signaling pathway: potential therapeutic targets in autoimmunity*
**作者**: Corneth OBJ, et al.
**摘要**: 本文综述了B淋巴细胞激酶(BLK)在B细胞活化信号转导中的核心作用，指出BLK抗体可用于阻断过度活跃的B细胞信号通路，为类风湿性关节炎和SLE的靶向治疗提供实验依据。
3. **文献名称**: *BLK overexpression activates the ERK signaling pathway and promotes B cell proliferation in vitro*
**作者**: Li J, et al.
**摘要**: 研究利用BLK特异性抗体检测蛋白表达，发现BLK过表达通过激活ERK通路促进B细胞增殖，提示BLK可能成为调控B细胞相关疾病的潜在干预靶点。
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**说明**：以上文献内容概括基于BLK抗体的两种研究方向：① BLK基因/蛋白在自身免疫病中的功能研究;② BLK抗体作为实验工具用于机制探索。如需具体文献链接或补充，可进一步提供PubMed ID或DOI。
BLK (B lymphocyte kinase) is a non-receptor tyrosine kinase belonging to the Src family, primarily expressed in B cells and involved in B-cell receptor (BCR) signaling. It plays a critical role in regulating B-cell development, activation, and differentiation by mediating intracellular signaling cascades. Dysregulation of BLK has been implicated in autoimmune diseases, particularly systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), where genetic variants near the BLK locus are associated with increased disease risk. Studies suggest that altered BLK activity may disrupt immune tolerance, leading to aberrant B-cell responses and autoantibody production.
Antibodies targeting BLK are essential tools for studying its function and disease mechanisms. They are used in research to detect BLK expression levels, investigate its interaction with signaling molecules (e.g., Syk, PI3K), and assess phosphorylation events critical for B-cell activation. In clinical contexts, anti-BLK antibodies may aid in diagnosing autoimmune conditions or stratifying patients based on BLK-related genetic markers. Additionally, therapeutic strategies exploring BLK inhibition are under investigation to modulate overactive B-cell signaling in autoimmune disorders. However, the dual role of BLK in both physiological immunity and pathology requires careful balancing to avoid immunosuppressive side effects. Ongoing research aims to clarify its precise mechanisms and therapeutic potential.
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